Baking Soda & Cancer (The Last Laugh)
University of Arizona Cancer Center member Dr. Mark Pagel will receive a $2 million grant from the National Institutes of Health to study the effectiveness of personalized baking soda therapy to treat breast cancer. In other words, clinical trials on the use of oral sodium bicarbonate for breast cancer treatments are about to start![1] Obviously there are people in the know who have understood that sodium bicarbonate (baking soda), that same stuff that can save a person’s life in the emergency room in a heartbeat, is a primary cancer treatment option of the safest and most effective kind.
Of course I feel vindicated for everything I wrote in Sodium Bicarbonate – Rich Man’s Poor Man’s Cancer Treatment, which still stands as the only full medical review on the subject of using simple baking soda in the practice of medicine. When taken orally with water, especially water with high magnesium content, and when used transdermally in medicinal baths, sodium bicarbonate becomes a first-line medicinal for the treatment of cancer, kidney disease, diabetes, influenza and even the common cold. And importantly, it is also a powerful buffer against radiation exposure, so everyone should be up to speed on its use. Everybody’s physiology is under heavy nuclear attack from strong radioactive winds that are circling the northern hemisphere.
Actually it is no surprise that a University of Arizona researcher received this grant because there has been cancer research going on for years there. Dr. Robert J. Gillies and his colleagues have already demonstrated that pre-treatment of mice with sodium bicarbonate results in the alkalinization of the area around tumors. The same researchers reported that bicarbonate increases tumor pH and also inhibits spontaneous metastases in mice with breast cancer.[2] It also reduces the rate of lymph node involvement.
I recently published about fungal infections, and breast cancer has been found to be associated with increased frequency of mold-fermented cheese consumption.[3] Fungi produce toxic metabolites called mycotoxins[4] that can cause cancer. Aflatoxin is a mycotoxin with carcinogenic potency that is found in inferior peanut butter and other nut and dairy products. Researchers in 1993 examined human breast cancer tissue and found significant carcinogenic aflatoxin within the cancer tissue implicating aflatoxin and thus fungus as a cause of breast cancer.[5]
The pH level of our internal fluids affects every cell in our body.
Chronic over-acidity corrodes body tissue, and if left unchecked
will interrupt all cellular activities and functions. In other words,
over-acidity interferes with life itself. It is at the root of cancer.
Sodium bicarbonate medical treatments are the time honored method to “speed up” the return of the body’s bicarbonate levels to normal. Sodium bicarbonate happens to be one of our most useful medicines as it treats the basic acid-alkaline axis of human physiology.
The pH of our tissues and body fluids is crucial and central because it affects and mirrors the state of our health or our inner cleanliness. The closer the pH is to 7.35-7.45, the higher our level of health and wellbeing. Staying within this range dramatically increases our ability to resist acute illnesses like colds and flues as well as the onset of cancer and other diseases. Keeping our pH within a healthy range also involves necessary lifestyle and dietary changes that will protect us over the long term while the use of sodium bicarbonate gives us a jump-start toward increased alkalinity.
The pH scale is like a thermometer showing increases and decreases in the acid and alkaline content of fluids. Deviations above or below a 7.35-7.45 pH range in the tightly controlled blood can signal potentially serious and dangerous symptoms or states of disease. When the body can no longer effectively neutralize and eliminate the acids, it relocates them within the body’s extra-cellular fluids and connective tissue cells directly compromising cellular integrity. Conversely when the body becomes too alkaline from too much bicarbonate in the blood, metabolic alkalosis occurs, which can lead to severe consequences if not corrected quickly.[6]
Jon Barron presents a way of looking at pH that opens up one of the major benefits of alkaline water:
Hydrogen ions tie up oxygen. That means that the more acid a liquid is, the less available the oxygen in it. Every cell in our body requires oxygen for life and to maintain optimum health. Combine that with what we know about hydrogen ions and we see that the more acid the blood (the lower its pH), the less oxygen is available for use by the cells. Without going into a discussion of the chemistry involved, just understand that it’s the same mechanism involved when acid rain “kills” a lake. The fish literally suffocate to death because the acid in the lake “binds up” all of the available oxygen. It’s not that the oxygen has gone anywhere; it’s just no longer available. Conversely, if you raise the pH of the lake (make it more alkaline), oxygen is now available and the lake comes back to life. Incidentally, it’s worth noting that cancer is related to an acid environment (lack of oxygen)—the higher the pH (the more oxygen present in the cells of the body), the harder it is for cancer to thrive.
Understanding this is important for two reasons: (1) it reveals one of the primary benefits of alkaline water—more “available” oxygen in the system and (2) it explains why alkaline water helps fight cancer.
The ocean, the mother of all life, has an average pH of about 8.1.
The ideal pH for blood sits at about 7.4, slightly alkaline—not acidic.
Jon Barron
Barron concludes:
If you’re eating well and living cleanly, then yes, you want to drink water with a naturally occurring pH only slightly above neutral. However, if you are eating the typical Western diet, high in meat, grains, sodas, and sugars that acidify the body, then you have a different problem. Your pH balance is now so far out of normal that you must go beyond normal in the other direction to counter it. My recommendation for daily drinking water pH is about 7.5-8—depending on how acid forming your diet is. Long-term consumption of higher pH water should be reserved for special circumstances. The most famous mountain waters in the world, waters renowned for their healing properties, are highly alkaline. I’m referring to the waters coming down from the Himalayas, and specifically to the waters of the Hunza Valley, which have a pH that runs between 9 and 11.
One does not have to be a doctor to practice pH medicine. Every practitioner of the healing arts and every mother and father needs to understand how to use sodium bicarbonate. Bicarbonate deficiency is a real problem that deepens with age so it really does pay to understand and appreciate what baking soda is all about.
[3] One sample study is by Le, et al. (1986), in a French case-control study of 1,010 breast cancer cases and 1,950 controls with nonmalignant diseases, found that breast cancer was found to be associated with increased frequency of mold fermented cheese consumption.
[4] Going, et al. (1990) found that weddellite (calcium oxalate) crystals are present in calcifications found in the breast tissue of patients with breast cancer. Calcium oxalate crystals are formed when calcium binds with oxalic acid. Oxalic acid is a mycotoxin that can be produced by a number of different fungal species. Some fungi produce such large amounts of oxalic acid that they are used for commercial production of chemicals. Aspergillus niger fungal infection in human lungs produces large amounts of oxalic acid.
[5] Researchers examined human DNA from a variety of tissues and organs to identify and quantify aflatoxin DNA-adducts. Such adducts are considered to be proof of the mycotoxin’s presence in a particular tissue.Their finding? “Tumor tissues had higher aflatoxin-adduct levels than did normal tissue from the same individual.”
[6] www.nlm.nih.gov/medlineplus/ency/article/001183.htm
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Do Medications Really Expire
Does the expiration date on a bottle of a medication mean anything? If a bottle of Tylenol, for example, says something like “Do not use after June 1998,” and it is August 2002, should you take the Tylenol? Should you discard it? Can you get hurt if you take it? Will it simply have lost its potency and do you no good?
In other words, are drug manufacturers being honest with us when they put an expiration date on their medications, or is the practice of dating just another drug industry scam, to get us to buy new medications when the old ones that purportedly have “expired” are still perfectly good?
These are the pressing questions I investigated after my mother-in-law recently said to me, “It doesn’t mean anything,” when I pointed out that the Tylenol she was about to take had “expired” four years and a few months ago. I was a bit mocking in my pronouncement – feeling superior that I had noticed the chemical corpse in her cabinet – but she was equally adamant in her reply, and is generally very sage about medical issues.
So I gave her a glass of water with the purportedly “dead” drug, of which she took two capsules for a pain in the upper back. About a half hour later she reported the pain seemed to have eased up a bit. I said “You could be having a placebo effect,” not wanting to simply concede she was right about the drug, and also not actually knowing what I was talking about. I was just happy to hear that her pain had eased, even before we had our evening cocktails and hot tub dip (we were in “Leisure World,” near Laguna Beach, CA, where the hot tub is bigger than most Manhattan apartments, and “Heaven” as generally portrayed, would be raucous by comparison).
Upon my return to NYC and high-speed connection, I immediately scoured the medical databases and general literature for the answer to my question about drug expiration labeling. And voila, no sooner than I could say “Screwed again by the pharmaceutical industry,” I had my answer. Here are the simple facts:
First, the expiration date, required by law in the United States, beginning in 1979, specifies only the date the manufacturer guarantees the full potency and safety of the drug – it does not mean how long the drug is actually “good” or safe to use. Second, medical authorities uniformly say it is safe to take drugs past their expiration date – no matter how “expired” the drugs purportedly are. Except for possibly the rarest of exceptions, you won’t get hurt and you certainly won’t get killed. A contested example of a rare exception is a case of renal tubular damage purportedly caused by expired tetracycline (reported by G. W. Frimpter et al., in the Journal of the American Medical Association, JAMA, 184:111, 1963). This outcome (disputed by other scientists) was supposedly caused by a chemical transformation of the active ingredient. Third, studies show that expired drugs may lose some of their potency over time, from as little as 5% or less to 50% or more (though usually much less than the latter). Even 10 years after the “expiration date,” most drugs have a good deal of their original potency. So wisdom dictates that if your life does depend on an expired drug, and you must have 100% or so of its original strength, you should probably toss it and get a refill, in accordance with the cliché, “better safe than sorry.” If your life does not depend on an expired drug – such as that for headache, hay fever, or menstrual cramps – take it and see what happens. One of the largest studies ever conducted that supports the above points about “expired drug” labeling was done by the U.S. military 15 years ago, according to a feature story in the Wall Street Journal (March 29, 2000), reported by Laurie P. Cohen. The military was sitting on a $1 billion stockpile of drugs and facing the daunting process of destroying and replacing its supply every two to three years, so it began a testing program to see if it could extend the life of its inventory. The testing, conducted by the U.S. Food and Drug Administration, ultimately covered more than 100 drugs, prescription and over-the-counter. The results showed that about 90% of them were safe and effective as far as 15 years past their original expiration date.
In light of these results, a former director of the testing program, Francis Flaherty, said he concluded that expiration dates put on by manufacturers typically have no bearing on whether a drug is usable for longer. Mr. Flaherty noted that a drug maker is required to prove only that a drug is still good on whatever expiration date the company chooses to set. The expiration date doesn’t mean, or even suggest, that the drug will stop being effective after that, nor that it will become harmful. “Manufacturers put expiration dates on for marketing, rather than scientific, reasons,” said Mr. Flaherty, a pharmacist at the FDA until his retirement in 1999. “It’s not profitable for them to have products on a shelf for 10 years. They want turnover.”
The FDA cautioned there isn’t enough evidence from the program, which is weighted toward drugs used during combat, to conclude most drugs in consumers’ medicine cabinets are potent beyond the expiration date. Joel Davis, however, a former FDA expiration-date compliance chief, said that with a handful of exceptions – notably nitroglycerin, insulin and some liquid antibiotics – most drugs are probably as durable as those the agency has tested for the military. “Most drugs degrade very slowly,” he said. “In all likelihood, you can take a product you have at home and keep it for many years, especially if it’s in the refrigerator.” Consider aspirin. Bayer AG puts two-year or three-year dates on aspirin and says that it should be discarded after that. However, Chris Allen, a vice president at the Bayer unit that makes aspirin, said the dating is “pretty conservative;” when Bayer has tested four-year-old aspirin, it remained 100% effective, he said. So why doesn’t Bayer set a four-year expiration date? Because the company often changes packaging, and it undertakes “continuous improvement programs,” Mr. Allen said. Each change triggers a need for more expiration-date testing, and testing each time for a four-year life would be impractical. Bayer has never tested aspirin beyond four years, Mr. Allen said. But Jens Carstensen has. Dr. Carstensen, professor emeritus at the University of Wisconsin’s pharmacy school, who wrote what is considered the main text on drug stability, said, “I did a study of different aspirins, and after five years, Bayer was still excellent. Aspirin, if made correctly, is very stable.
Okay, I concede. My mother-in-law was right, once again. And I was wrong, once again, and with a wiseacre attitude to boot. Sorry mom. Now I think I’ll take a swig of the 10-year dead package of Alka Seltzer in my medicine chest – to ease the nausea I’m feeling from calculating how many billions of dollars the pharmaceutical industry bilks out of unknowing consumers every year who discard perfectly good drugs and buy new ones because they trust the industry’s “expiration date labeling.”
http://www.redflagsweekly.com/altschuler/200
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Wheat: The Addictive Opiate
Although it is a central premise of the whole Wheat Belly argument, I fear that some people haven’t fully gotten the message:
Modern wheat is an opiate.
And, of course, I don’t mean that wheat is an opiate in the sense that you like it so much that you feel you are addicted. Wheat is truly addictive.
Wheat is addictive in the sense that it comes to dominate thoughts and behaviors. Wheat is addictive in the sense that, if you don’t have any for several hours, you start to get nervous, foggy, tremulous, and start desperately seeking out another “hit” of crackers, bagels, or bread, even if it’s the few stale 3-month old crackers at the bottom of the box. Wheat is addictive in the sense that there is a distinct withdrawal syndrome characterized by overwhelming fatigue, mental “fog,” inability to exercise, even depression that lasts several days, occasionally several weeks. Wheat is addictive in the sense that the withdrawal process can be provoked by administering an opiate-blocking drug such as naloxone or naltrexone.
But the “high” of wheat is not like the high of heroine, morphine, or Oxycontin. This opiate, while it binds to the opiate receptors of the brain, doesn’t make us high. It makes us hungry.
This is the effect exerted by gliadin, the protein in wheat that was inadvertently altered by geneticists in the 1970s during efforts to increase yield. Just a few shifts in amino acids and gliadin in modern high-yield, semi-dwarf wheat became a potent appetite stimulant.
Wheat stimulates appetite. Wheat stimulates calorie consumption: 440 more calories per day, 365 days per year, for every man, woman, and child. (440 calories per person per day is the average.) We experience this, sense the weight gain that is coming and we push our plate away, settle for smaller portions, increase exercise more and more . . . yet continue to gain, and gain, and gain. Ask your friends and neighbors who try to include more “healthy whole grains” in their diet. They exercise, eat a “well-balanced diet” . . . yet gained 10, 20, 30, 70 pounds over the past several years. Accuse your friends of drinking too much Coca Cola by the liter bottle, or being gluttonous at the all-you-can-eat buffet and you will likely receive a black eye. Many of these people are actually trying quite hard to control impulse, appetite, portion control, and weight, but are losing the battle with this appetite-stimulating opiate in wheat.
Ignorance of the gliadin effect of wheat is responsible for the idiocy that emits from the mouths of gastroenterologists like Dr. Peter Green of Columbia University who declares:
“We tell people we don’t think a gluten-free diet is a very healthy diet . . . Gluten-free substitutes for food with gluten have added fat and sugar. Celiac patients often gain weight and their cholesterol levels go up. The bulk of the world is eating wheat. The bulk of people who are eating this are doing perfectly well unless they have celiac disease.”
In the simple minded thinking of the gastroenterology and celiac world, if you don’t have celiac disease, you should eat all the wheat you want . . . and never mind about the appetite-stimulating effects of gliadin, not to mention the intestinal disruption and leakiness generated by wheat lectins, or the high blood sugars and insulin of the amylopectin A of wheat, or the new allergies being generated by the new alpha amylases of modern wheat.
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Big Pharma Whistles, and the Drug Enforcement Administration Comes Running
The DEA is enabling—even encouraging—a generation of opiate addicts, while the FDA tries to quash safe and helpful supplements like DHEA.
Goodness, the legal drug-makers have been busy! This week the Associated Press revealed that in 2010, US pharmacies dispensed the equivalent of 69 tons of pure oxycodone (used as ingredient in OxyContin, Percocet, and Percodan) and 42 tons of pure hydrocodone (used in Vicodin, Norco, and Lortab). That’s enough to give forty 5-milligram Percocets and twenty-four 5-milligram Vicodins to every single person in the United States.
The production and sale of both drugs has increased tremendously over the past decade; in some locations, sales have increased by 1,500 percent. Distribution is particularly high in Appalachia, the Midwest—particularly suburbia—and the Southwest.
Why the increase? Our poor diets and inactive lifestyles increase inflammation and pain. Older people are especially vulnerable in this regard. And doctors are increasingly willing to treat pain with drugs. Sales are also being driven by addiction, as users become physically dependent on painkillers and begin “doctor shopping” to keep the prescriptions coming.
As with all opiates, oxycodone and hydrocodone bind to opiate receptors in the brain, blocking not only pain signals but any negative emotions like stress or anxiety. The euphoria associated with early use fades relatively quickly as tolerance builds. The pain-managing efficacy will also be reduced as tolerance builds—which is why these drugs should not be used for long-term or chronic pain. If users take the drug for longer than prescribed, or in higher doses, it is likely that they will become addicted.
Addicts die from drug overdoses at a much higher rate than the rest of the population. Opioid pain relievers like oxycodone and hydrocodone caused 14,800 overdose deaths in 2008. Addiction is also responsible for the alarming rise in pharmacy robberies nationwide.
The epidemic is not likely to abate soon. The explosion of pain management clinics in Florida, dubbed “pill mills,” prompted the state legislature to close a loophole that had allowed physicians to fill oxycodone prescriptions on the spot. Authorities say a half-billion doses of the drug and its generic equivalents were distributed in the state during 2009 alone. An unknown number wound up in the hands of “patients” who had come from out of state to have prescriptions filled by multiple pill mills, before driving home to resell the pills on the black market.
According to Gene Haislip, who for seventeen years was head of the Drug Enforcement Administration’s Office of Diversion Control, the DEA’s policy of allowing increases in the production of these drugs in the face of widespread illegal and non-medical use shows a “serious lack of accountability and oversight”:
The DEA is the lone federal agency with the power to decide how much of the drug gets made and put out there; it alone has had all the responsibility to do something about this problem. The way I did it for seventeen years, which was basically the way it had always been done even before the DEA was the DEA, is that when a significant diversion problem occurred, the quota increase requests would come under greater scrutiny. With Oxy, there has been a significant diversion problem since the late 1990s, so the requests should have come under greater scrutiny.
That apparently didn’t happen, Haislip says. Instead, the DEA has rubber-stamped Big Pharma’s requests to increase oxycodone production. And why is that? Political influence, plain and simple.
As Marcia Angell, former editor of the New England Journal of Medicine, pointed out in her 2004 book The Truth about the Drug Companies, the Pharmaceutical Researchers and Manufacturers of America (PhRMA) employs more lobbyists in Washington than there are members of Congress. Since 2007, the group has spent more than $20 million annually on lobbying in Washington to see that its interests are protected. Haislip says DEA won’t block a company’s requested quota increase “if that company is supporting members of Congress who have the power to block the agency’s funding.”
Then there’s the revolving door between the Office of Diversion Control and drug manufacturers or consulting firms that work with both industry and DEA. People working in the Office of Diversion Control know they might get lucrative work with drug companies upon retirement, and this constitutes a huge conflict of interest that prevents DEA officials from doing their duty. They certainly aren’t going to offer an opinion or do something that’s going to cut off their future prospects.
Contrast the “hands-off” approach dealing with incredibly addictive narcotics with the aggressive disapproval of perfectly safe supplements like DHEA. DHEA, which is short for dehydroepiandrosterone, is a natural hormone produced by the adrenal glands, the gonads, and the brain. DHEA is the most abundant circulating steroid hormone in humans and is sometimes referred to as the mother hormone since other hormones can be made from it. In its supplement form, DHEA is used for slowing or reversing aging, improving thinking skills in older people, slowing the progress of Alzheimer’s disease, weight loss, decreasing the symptoms of menopause, and boosting the immune system.
As we reported last October, DHEA supplementation also helps create improvements in muscle strength and bone mineral density with a reduction in body fat mass. And there is substantial support for its effectiveness in fighting adrenal insufficiency, hypopituitarism, general osteoporosis, systemic lupus, depression, schizophrenia, and balancing the overproduction of cortisol produced by excessive stress. Too much cortisol ages us rapidly; a little extra DHEA can make all the difference.
There are a number of different forms of DHEA. 5-DHEA is the form most commonly sold on the market and used for aging, depression, obesity, cardiovascular risk, and adrenal insufficiency. However, it can result in an increased production of male hormones, which may be positive or negative depending on various factors. For example, some aging males convert extra testosterone to estrogen, a process called aromatization, and too much in women can cause unwanted hair growth. For men with prostate troubles, 1-DHEA might be a better choice (no estrogenicity and decreased androgenicity), while 19Nor-DHEA might be better for women (little estrogenicity and anti-androgenic metabolites). But these little-known forms of DHEA are especially vulnerable to being lumped together with dangerous drugs and banned—simply because they are not well known.
DHEA has had a fifteen-year record of complete safety. Despite this, FDA and certain members of Congress keep trying to regulate it as a controlled substance, specifically as an anabolic steroid, even when used in dietary supplements.
Currently DHEA could be classified as an illegal anabolic steroid if the DEA were to present evidence that it meets all eight requirements under the Anabolic Steroids/Controlled Substances law. As the DEA has not yet put DHEA on the list, they clearly either don’t think it fits or hesitate for other reasons. Legislation was introduced a few years ago to add DHEA to the DEA’s controlled substances list, even though DEA already had the power to put it on the list if they met the burden of proof.
No deaths from DHEA. No addictions. No shameful deals between the manufacturer and federal agencies. No organized crime because of DHEA in America’s heartland. And yet DHEA is under attack, while big Pharma keeps churning out dangerous opiates by the ton.
Source: http://www.anh-usa.org/big-pharma-whistles-and-dea-comes-running/
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Herbal remedy blamed for high cancer rate in Taiwan: study
A toxic ingredient in a popular herbal remedy is linked to more than half of all cases of urinary tract cancer in Taiwan where use of traditional medicine is widespread, said a US study Monday.
Aristolochic acid (AA) is a potent human carcinogen that is found naturally in Aristolochia plants, an ingredient common in botanical Asian remedies for aiding weight loss, easing joint pain and improving stomach ailments.
The ancient herb has been touted around the world for thousands of years for everything from gout to childbirth, but scientists now know it carries serious risks of causing kidney disease and urinary cancers.
The latest research found it can interact with a person’s DNA and form unique biomarkers of exposure, as well as creating signals within tumor suppressing genes that indicate the carcinogen has been ingested.
In Taiwan, where previous research has shown about one-third of the population has taken AA in recent years, rates of urinary tract and kidney cancer are about four times higher than in Western countries where use is less common, said the findings in the Proceedings of the National Academy of Sciences.
“It is a rare tumor and Taiwan has the highest incidence of any country in the world,” said lead author Arthur Grollman of the department of pharmacological sciences at Stony Brook University in New York.
“The fact that Taiwan had the highest incidence both of cancer and this renal disease — that was our clue that something was going on there,” Grollman told AFP.
The research was based on 151 patients with urinary tract cancer, of whom 60 percent showed specific mutations linked to the herbal remedy.
In particular, after being ingested the acid forms a unique kind of lesion in the renal cortex, and also gives rise to a particular mutational signature in the TP53 tumor suppressing gene, said the study.
The herb is known in Europe by the name birthwort because it was often given to women during childbirth. Derived from the Greek, “aristolochia” means noble birth.
“This has been used by every culture in the world from the earliest written record,” said Grollman.
Signs of harm have emerged in recent decades, and the acid is blamed for causing a kidney disease called Balkan endemic nephropathy, first described in 1956, that afflicted rural farmers in Bosnia and Herzegovina, Bulgaria, Croatia, Romania and Serbia.
The villagers were found to be baking seeds from a weed called Aristolochia clematitis in their bread.
In the 1990s, a group of Belgian women reported sudden late stage kidney failure after taking a weight loss drug that contained AA.
And even though many countries have taken steps to warn of the risks, the ingredient is difficult to control and still finds its way into products via the Internet, said Grollman, adding that most of the AA products currently being used in Taiwan are made in China.
“Many countries ban it but it is always available on the Internet. And in fact you can’t ban it in the United States. You can only ban its importation.”
The US Food and Drug Administration warned of the risks of aristolochic acid in 2001 after two patients developed serious kidney disease after using botanical products containing it.
“Natural is not necessarily safe, nor is long-term usage,” said Grollman.
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Drugs May Cause 5 Times More Side Effects Than Previously Thought
Prescription medications usually always carry a rather frightening (and long) list of possible side effects. These drug side effects may range from mild symptoms like headache or nausea to more serious risks such as seizures or temporary blindness. New research suggests that the side effects listed on the label often represent just a small portion of what users are really experiencing.
The Truth about Clinical Trials
Most new prescription drugs undergo extensive testing in laboratories, often on animals, before being the center of a variety of clinical trials among closely monitored patients. While these studies are generally very thorough and are the most reliable way to prove that a medication is safe and effective, clinical trials could not possibly foresee all of the potential effects the drug could have on individuals with different underlying conditions and medical histories. Many times, the most serious side effects are not acknowledged until after the medicine has been on the market for quite some time.
How Additional Side Effects Are Determined
Once a drug is approved by the FDA for specific treatments and medical providers begin to prescribe the medication to their patients, it is not uncommon for many other adverse effects to emerge. Unfortunately, it’s not always easy to determine if the symptoms are a direct result of the medication or if other factors are also to blame. All of these reactions and side effects are added to more than 4 million similar reports in the FDA Adverse Event Reporting System database. Until recently, no one had devised a logical method to analyze and filter the data.
New Advancements in Data Research
A team of researchers from Stanford University School of Medicine have developed such a system. Using a computer generated algorithm, graduate student Nicholas Tatonetti and Stanford professor Russ Altman, MD, PhD sorted the millions of reported side effect cases within the database to group together patients with similar lifestyles, medical histories, and/or prescriptions. This process makes it easy to determine the cause of the side effect or reaction, and is also a great way to learn more about adverse drug interactions that may not yet be acknowledged.
Results of the Study
Two separate databases were created to organize the findings of this research and both are available to the public. The first, OFFSIDES, discovered an additional 329 side effects on average for each of the 1,332 drugs that were studied – nearly 5 times the 70 or so potential reactions that are listed on the average drug insert.
The TWOSIDES database relates to drug interactions and is based on more than 50,000 possible medication combinations. An additional 1,301 contraindications were discovered. One of the most important findings is a previously unknown risk of fatal cardiac conditions in patients taking SSRI class antidepressants at the same time as a commonly prescribed blood pressure medication.
While the results of this study are quite alarming, this method of analyzing data will be very beneficial to the medical industry as well as the patients taking the drugs. It may take several years before many of the newly discovered side effects and interactions are mandatorily included in the medication packaging, but doctors and their patients can use the knowledge to determine the most effective prescription combinations for the specified conditions.
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Dr. Abram Hoffer on the Treatment of Schizophrenia
Dr. Abram Hoffer, MD (Medical Doctor), PhD (Doctor of Philosophy), RNCP (Registered Nutritional Consulting Practitioner), founder of The Orthomolecular Vitamin Information Centre.
I have a PhD from the University of Minnesota, a Medical Degree from Toronto. I’m a Fellow Neuropharmacology Physician in Canada. I became Director of Psychiatric Research in the Province of Saskatchewan of the Department of Public Health in 1950 until 1967. I was Associate Professor of Psychiatry at the University of Saskatchewan; at that time I was in charge of very large research programs and we became known for our work in psychedelic drugs.
Orthomolecular Treatment for Schizophrenia. COMBAT SCHIZOPHRENIA WITH THE MEGAVITAMIN AND NUTRITIONAL STRATEGIES OF ORTHOMOLECULAR PSYCHIATRY – Schizophrenia is a disease and syndrome with biochemical origins that has the hallmarks of debilitating perceptual disorders and thought disturbances. Orthomolecular psychiatry, a treatment strategy that uses megadoses of vitamins B-3 and C in conjunction with correct nutrition, yields a 90 percent recovery rate in acute cases and up to 50 percent in chronic patients. This guide by the cofounder of orthomolecular therapy offers a step-by-step approach so that patients and their families will get the maximum benefits from treatment.
From the Publisher
THE MAGIC OF ORTHOMOLECULAR TREATMENT – Orthomolecular treatment of schizophrenia is a comprehensive approach that includes megavitamin therapy, nutrition, and counseling of both patient and family members. This guide, written by a cofounder of orthomolecular psychiatry, outlines the strategies you will need to get an informed diagnosis, proper treatment, and appropriate, flexible follow-up for the schizophrenic patient.
In fact, there’s a film called Psychedelic Pioneers, which on the first 10 years of our research, when we made our major discoveries about Schizophrenia and about the use of vitamins as a potentially good treatment.
In 1967, I resigned from my two jobs. They were nice cushy jobs. I didn’t have to do anything. I could have stayed there forever until I retired when I turned 65, but I didn’t want to. I wanted to help patients.
I opened a private practice in Saskatoon, moved to Victoria in 1976. At the end of that year, I surrendered my medical license for many reasons. I opened up a new business, The Orthomolecular Vitamin Information Centre. That year I was sitting in the office of OVIC (Orthomolecular Vitamin Information Centre).
Can you explain what orthomolecular is?
It was a term developed by Dr. Linus Pauling who was a good friend of mine. “Ortho” means correct. Molecule, molecule, we know what that is. [ Molecule: The smallest particle of a substance that retains the chemical and physical properties of the substance and is composed of two or more atoms; a group of like or different atoms held together by chemical forces. ]
Dr. Linus Pauling implied that the human body would function normally as long as it was able to obtain the right natural molecules that it needed in order to survive. As long as the body had the right number of amino acids, vitamins, minerals, hormones, and all these other things [nutrients], it was okay. Orthomolecular Medicine meant that we would emphasize the use of these natural components to provide treatment on the assumption that in most cases there was something wrong in these different elements [vitamins, minerals, amino acids and fatty acids, hormones, enzymes, etc.].
Dr. Linus Pauling published the term “Orthomolecular Medicine” in 1968 in an article in Science Magazine. It was a very major article. The term, Orthomolecular Medicine, was accepted with hostility, fantastic hostility and the medical community became extremely hostile to Dr. Pauling. They hadn’t heard about me so I didn’t get any of that hostility. But Dr. Pauling was a double Nobel Prize winner so he stuck his foot out. They said he was a mere PhD, in fact he had 48 of them. He also had many DSEs, Doctor of Science. But they [the medical community] said he ought not to be making any statements about the use of vitamins. In fact, it was Dr. Linus Pauling’s work with the structure of molecules and the reactions of molecules within the body that created the basis for modern medicine today.
Orthomolecular Medicine means we emphasize proper nutrition; the use of vitamins in adequate quantities, which may mean large or small. Minerals, we use everything we can to help our patients get well. We are not against drugs. We are against the ways in which drugs are used today. We are in favour of the proper use of drugs. That is, in minor quantities and get the patient off as soon as you can. So, that’s Orthomolecular Medicine.
What sort of results have you found using orthomolecular medicine?
The main difference is that our patients get well. Now, the term “cure” does not exist in psychiatry. You didn’t know that, did you? If you look in the standard psychiatric dictionary, the word “cure” has been deleted because the average psychiatric point of view is that you cannot cure anyone. You cannot cure them, you can help them. You can relieve them of some of the symptoms but you cannot cure them. So that’s why they are contend ??? with some of the schizophrenic patients, who are placed on heavy medication so he’s no longer hallucinating, he’s not longer hearing voices, and seeing visions. The fact now that he can’t function; he’s sitting at home salivating and watching television all day, psychiatrists think that’s great. After all, that’s all they’re expected to do, they’re expected to merely get them out of the hospital so they can stay at home and let their family worry about them.
On the other hand, we don’t have that view. My friends and I, in the field of orthomolecular psychiatry, we are aiming at recovery. A young patient I saw in 1973, I think it was, when he was 15 or 16, he was schizophrenic. I started him on the orthomolecular approach which meant paying attention to the right nutrition. Getting him off junk food, getting him on the right vitamins which in his case was vitamin B3, niacin. I think it was niacin. I only saw him once or twice because at that time I left Saskatoon to come here [Victoria, B.C.], so I couldn’t see him anymore. Today he is on the Professorial Staff at Oxford University in England. He’s normal, he’s been normal ever since.
I’ve seen over 5,000 schizophrenic patients. I know 17 men who were Schizophrenic in their teens, who recovered and became doctors. One today heads up a Pediatric clinic; he’s a graduate of Harvard University. One today is the head of a large psychiatric department in an American University. The third one became the head of the Canadian Psychiatric Association; he had been a patient of mine. These were young men who were seriously sick and who became doctors and who were able to practice.
[With orthomolecular medicine] We are aiming toward recovery. We can’t always get there, but we try. There are 4 things you have to do to help people get well.
1. You have to give them shelter. You never get the homeless well. You cannot treat the homeless and half the homeless are schizophrenic. They’ve been very shabbly treated. There are no shelter.
2. Secondly, you have to have good food. You have to have really good food, as we all agree with that.
3. They have to be treated with civility; they have to be treated with respect. They have to be treated as humans. Today, unfortunately, in psychiatry, too often the patients are not treated that way at all. They’re badly treated, mistreated. They’re forced to take injections against their will, even though that’s against the law in Canada.
4. The fourth aspect of treatment is what I call orthomolecular. They have to be given the right combination of nutrition, vitamins, minerals, and medication if necessary. But the medication has to be used carefully and all to make sure the medication is not damaged in that process.
The main message has to be that we have to change the system. The system is sick and corrupt. We have to change the system. Eventually we have to make the medical profession accountable. Someone has to ask the medical professional, “Why do you tolerate this?” We have to ask them that. What we need in Canada is an independent commission headed by a Judge, broad-sweeping commission to actually examine the whole issue, “Why is the medical profession not being held accountable?”
If you blame anyone, who do you blame? You blame the drug companies? You blame the hospitals? You blame the government for not putting enough money in the system? You blame the food supply? Have you ever heard of anyone saying to the medical profession, “How come you don’t do a better job?” Have you ever heard that? Well, I think this has to be examined.
If you go to a hospital and you say, “Why don’t you do better job?” They’ll say I will, give me more money, give me more staff, more doctors, more nurses. They don’t give a damn. You can give them 10 times more doctors. If you have the wrong treatment, the patients still won’t get well.
Big Pharma controls medicine today. They give huge grants to the medical schools. Often times, these medical schools don’t have time to do any other studies. They just obediently work for the drug companies. Big Pharma controls everything. In the United States alone, in [2006] they spent $19 billion dollars, $19 billion dollars a year advertising to doctors. They claim the advertising doesn’t persuade doctors, which is kind of funny. If the advertising didn’t persuade doctors, why would Big Pharma spend $19 billion trying to do that? They control the journals. Any medical journal today that you pick up, at least half the pages are drug ads. You’ll never find an ad for good food, you won’ find an ad for vitamins, you won’t find an ad for holistic health. You won’t find an ad for these things.
We are really in a terrible situation. The system is really sick. You can quote me literally. I think the system is absolutely sick and it has to be changed. I’m not the only one who says that. The Province of Ontario said the same thing. The latest Senate Committee by Senator Kirby said the same thing. If you read his report, he says [the healthcare system] is dysfunctional. He called the Canadian Health Care system dysfunctional. That means it’s sick. All these people who have looked at it, studied it, written books about it, all maintain that the healthcare system is sick. And I agree. We have to do something about it.
What do you think we should do?
We have to do what you’re doing. We have to inform the public. We have to let the public know exactly what is happening. Because right now, they don’t know.
ORTHOMOLECULAR VITAMIN INFORMATION CENTRE Inc.
2717 Roseberry Avenue, Victoria, British Columbia, Canada V8R 3V1
Telephone 250-386-8756 Fax 250-590-8757
ffuller@islandnet.com
http://www.orthomolecularvitamincentre.com/




